Antibacterial drug is ampicillin – an antibiotic from the group buy proviron online of semisynthetic penicillins, which has a bactericidal effect on sensitive organisms during the active reproductive phase by inhibiting the biosynthesis of the cell wall peptidoglycan. Sulbactam has no clinically significant antibacterial activity (with the exception of Neisseriaceae and Acinetobacter), it is an irreversible inhibitor of most major beta-lactamases, which are produced by microorganisms that are resistant to beta-lactam antibiotics. Sulbactam is also associated with several penicillin binding proteins, however, some strains are more susceptible to the combination than one beta-lactam buy proviron online antibiotic. buy proviron online active against a broad spectrum of gram-positive and gram-negative bacteria including Staphylococcus aureus and Staphylococcus epidermidis (including penicillin-resistant and some methicillin-resistant strains);Streptococcus pneumoniae, Streptococcus faecalis and the other Streptococci, Haemophilus influenzae and Haemophilus parainfluenzae (producing strains not producing beta-lactamase), Branhamella catarrhalis, Escherichia coli, Klebsiella spp., Proteus spp. (indolpolozhitelnye and indolotritsatelnye), Morganella morganii, Citrobacter spp. and Enterobacter spp, Neisseria meningitidis proviron hair loss and Neisseria gonorrhoeae.; anaerobes, including Bacteroides fragilis, Peptococcus spp., Peptostreptococcus spp. and close to it types.
Pharmacokinetics buy proviron online well absorbed when taken orally without being destroyed in the acidic environment of the stomach. It penetrates into most tissues and body fluids. Poorly penetrates the blood-brain barrier. Write mainly kidneys, and urine are very high concentrations of unchanged antibiotic and bile and breast milk. buy proviron online after repeated administration has not accumulates, which makes it possible to use it for a long time in large doses.
Indications Infectious-inflammatory diseases, caused by susceptible microorganisms: infections of the upper, lower respiratory tract and LOP-organs (including sinusitis, otitis media and epiglottitis, bacterial pneumonia);infections of the urinary and genital organs (including pyelonephritis, endometriosis, cystitis, urethritis); biliary tract infections (cholecystitis, cholangitis); infections of the skin and soft tissues; infections of bones and joints; gonococcal infection.
Contraindications : Hypersensitivity to ampicillin and sulbactam and other beta-lactam antibiotics, infectious mononucleosis, lymphatic leukemia, severe violations of the liver and kidneys, children under 3 years (when using tablets).
Pregnancy and lactation If necessary, use during pregnancy should assess the expected benefit to the mother and the potential risk to the fetus. If necessary, use during lactation should stop breastfeeding.
Dosing and Administration Inside. Adults and children weighing more than 30 kg of the drug is prescribed for the 375 – 750 mg per day. For children weighing less than 30 kg are given 25 – 50 mg per kg patient body weight per day (depending on the severity of the infection). The daily dose is given in two doses. The course of treatment is from 5 to 14 days. In the treatment of uncomplicated gonorrhea sultamicillin can be assigned to a single dose of 2250 mg (6 tablets) (preferably in combination with 1000 mg probenecid). Babies preferred use of the drug as a suspension.
A method for preparing a slurry The slurry is prepared immediately prior to the first application. The powder can be dissolved boiled water cooled to room temperature, shaking and gradually adding water to the mark on the vial. Then let stand for about 5 minutes to ensure complete dissolution. The bottle should be shaken well before each use. You should use the measuring spoon, which should be well rinsed with water after each use to exact dosage of the drug. After dilution suspension should be kept not more than 14 days in the refrigerator, but not frozen.
Side effects: Allergic reactions: rash, redness of the skin, angioedema, rhinitis, conjunctivitis, fever, arthralgia, eosinophilia, in rare cases, rash, pruritus, rarely – bronchospasm, eosinophilia, serum sickness, anaphylaxis, very rarely met: erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis. On the part of the gastrointestinal tract : nausea, vomiting, decreased appetite, diarrhea, pseudomembranous enterocolitis primobolan cycle results, liver dysfunction (increased activity of “liver” transaminases, cholestatic jaundice). From the side of hematopoiesis and hemostasis system : anemia, hemolytic anemia, leukopenia, neutropenia, lymphopenia, thrombocytopenia and eosinophilia. From the nervous system: drowsiness, malaise, headache, rarely reported occurrence of seizures. Laboratory tests : transient increase in alanine aminotransferase (ALT) and aspartate aminotransferase (the ACT), hyperbilirubinemia, azotemia, increasing concentrations of urea, hypercreatininemia. Other : very rarely reported cases of interstitial nephritis, long-term treatment – superinfection caused by resistant to malaria infections (candidiasis).
Overdose symptoms arising from drug overdose, differ significantly from its side effects. It will be appreciated that high concentrations of beta-lactam antibiotics in spinal fluid may cause damage to the central nervous system including convulsions. How to ampicillin and sulbactam are removed from the circulation by hemodialysis. Treatment : gastric lavage, symptomatic therapy, hemodialysis (especially in patients with impaired renal function).
Interaction with other drugs Anticoagulants : Penicillins may alter platelet aggregation and blood coagulation indicators (increase the effect of anticoagulants). The preparations have bacteriostatic (chloramphenicol, erythromycin, sulfa drugs and tetracyclines ): antagonistic effect. The bactericidal antibiotics (including aminoglycosides , cephalosporins, cycloserine, vancomycin, rifampicin) have a synergistic effect. Antacids, glucosamine, laxatives, drugs, food, aminoglycosides (with enteral appointment) slow down and reduce the absorption of : ascorbic acid increases absorption. oral contraceptives containing estrogen : reduces the effectiveness of oral contraceptives, drugs, which is formed during the metabolism of para-aminobenzoic acid, and ethinyl estradiol (risk of bleeding “breakthrough”).methotrexate : penicillins coadministration resulted in a decrease in clearance and methotrexate to increase its toxicity. Such patients should be carefully monitored. Probenecid, diuretics, allopurinol, phenylbutazone, nonsteroidal anti-inflammatory drugs and other. Drugs that reduce tubular secretion , increase the concentration of ampicillin and sulbactam in plasma, leading to a longer conservation of blood, lengthening half-life and increases the risk of toxicity . Effects on laboratory parameters : non-enzymatic methods for determining the sugar in urine using Benedict’s reagent, Fehling’s or Klinitesta can give a false positive result. It was noted that the use of ampicillin in pregnant women resulted in a transient reduction in plasma total associated estriol levels, estriol-glucuronide, and estrone and estradiol bound. Allopurinil : increases the risk of skin rash.
in the treatment of penicillin described serious and sometimes fatal allergic (anaphylactic) reaction. In the case of an allergic reaction, you must stop the drug and appropriate treatment. If necessary, prescribe epinephrine, oxygen, glucocorticosteroid hormones intravenously and take measures to improve airway management, including intubation. In the treatment of patients with sepsis may develop bacteriolysis reaction (Jarisch-Herxheimer). As with any antibiotic, is essential constant monitoring in order to detect signs of overgrowth of non-susceptible organisms, including fungi. When superinfection drug should be discontinued and / or adequate therapy. During long-term therapy the drug is recommended to periodically monitor the performance of the functions of internal organs, including the kidneys, liver and hematopoietic system. This is particularly important for the newborn (especially preterm) and young children.
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Form release tablets, film-coated, 375 mg: 10 tablets in amber glass vial Type III of, screwed aluminum or plastic lid. In the bottle is placed a plastic cylindrical container with a desiccant (silica gel) in size, characterized by tablets, or a container with a desiccant inserted into the vial cap (part seal). 1 bottle in a cardboard box with instructions for use. 200 bottles (2000 tablets) in a cardboard box (for hospitals) with an equal number of instructions for use. The powder for suspension for oral administration of 250 mg / 5 mL: in bottles of 40 ml or 70 ml amber glass type III with Valium, a sealed aluminum cap. 1 bottle in a cardboard box together with measuring spoon and instructions for use. 100 vials with instructions for use in a cardboard box (for hospitals).
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